Biography
I am a researcher specializing in medical immunology, respiratory diseases, and autoimmune disorders. I earned a BSc in Biology from Salahaddin University-Erbil (SUE) in 2013, followed by an MSc in Immunology in 2016, focusing on autoimmune diseases, and a PhD in Medical Immunology from SUE in 2023, in collaboration with Tabriz University, Iran.
My research primarily investigates the relationship between gene polymorphisms and susceptibility to, as well as severity of, various immunological disorders. I utilize a range of molecular techniques to uncover the underlying mechanisms of these disorders, with a strong emphasis on immunogenetics. My work spans both animal models and clinical samples, providing critical insights into disease causation and the identification of novel biomarkers for diagnosis and severity assessment.
Additionally, my research aims to contribute to the development of targeted therapies and personalized medicine approaches, particularly for autoimmune diseases and respiratory conditions. By bridging experimental immunology with clinical applications, I seek to enhance our understanding of how genetic variations influence immune system responses, offering new perspectives on disease prevention and treatment.
Published papers
1. ABDOLMALEKI, A., KHUDHUR, Z. O., SMAIL, S. W., ASADI, A. & AMANI, A. 2023. FeCo-Chitosan/DNA nanoparticles for gene transfer to MCF-7 breast cancer cells: preparation and characterization. Basic & Clinical Cancer Research. https://doi.org/10.18502/bccr.v13i4.14399
2. ISHAQ, S. E., ABDULQADIR, S. Z., OMAR, S. A., QADIR, M. K., KHDIR AWLA, H., RASUL, M. F., BAPIR, A. A., ZANICHELLI, A., MANSOOR, M. K. SMAIL, S. W., & KALEEM, M. 2021. Comparative study of SARS-CoV-2 antibody titers between male and female COVID-19 patients living in Kurdistan region of Iraq. Gene Reports, 25, 101409. https://doi.org/10.1016/j.genrep.2021.101409
3. JALAL AHMED, H., OMAR KHUDHUR, Z., SAADI JUMAAH, S. SMAIL, S. W., & YASIN KARIM, A. 2022. Does the cytomegalovirus infection cause kidney transplant rejection in Erbil city patients, Kurdistan region of Iraq? Zanco Journal of Pure and Applied Sciences, 34. https://doi.org/10.21271/zjpas
4. KHUDHUR, Z. O., OTHMAN, G., OTHMAN, G. O., JAFAAR, A. M., QADIR, M. K., AWLA, H. K., QASIM, S. S., HADI, S. M., KHAN, S. S., NOREEN, & S. SMAIL, S. W., 2023. Lack of association between the eNOS rs1800779 (A/G) polymorphism and the myocardial infarction incidence among the Iraqi Kurdish population. Journal of Taibah University Medical Sciences, 18, 162-169. https://doi.org/10.1016/j.jtumed.2022.08.006
5. MIASKO, M. H., SMAIL, S. W., KARIM, A. Y., QADIR, M. K., BAPIR, A. A., OMAR, S. A., ISMAIL, I. I., SMAIL, S. W.,TAHA, O. S., KHUDHUR, Z. O. & JALAL, K. F. 2020. Association study of polymorphisms at A66G (rs1801394) of MTRR gene and autism spectrum disorders in a Kurdish population. Gene Reports, 21, 100949. https://doi.org/10.1016/j.genrep.2020.100949
6. OMAR KHUDHUR, Z., ZIYAD ABDULQADIR, S., FAQIYAZDIN AHMED MZURY, A., AZIZ RASOUL, A., SMAIL, S., GHAYOUR, M. B. & ABDOLMALEKI, A. Epothilone B loaded in acellular nerve allograft enhanced sciatic nerve regeneration in rats. Fundamental & Clinical Pharmacology, n/a. https://doi.org/10.1111/fcp.12961
7. QADER, G., AALI, M., SMAIL, S. W., MAHMOOD, K., HASAN, B., KARWAN, M., RAHMAN, D. B., QADIR, F. A., MOHAMMAD, D. K. & NAJMULDEEN, H. H. 2021. Cardiac, hepatic and renal dysfunction and IL-18 polymorphism in breast, colorectal, and prostate cancer patients. Asian Pacific Journal of Cancer Prevention: APJCP, 22, 131. https://doi.org/10.31557/APJCP.2021.22.1.131
8. QADIR, F. A., PIRDAWID, A. O., AALI, M. H., SMAIL, S. W., KHUDHUR, Z. O., SHAREEF, A. A., AWLA, H. K., QADIR, M. K., RAJAB, M. F. & SHEKHA, M. S. 2020. Association study of Interleukin 10 gene polymorphisms in Iraqi patients with multiple sclerosis. Gene Reports, 21, 100948. https://doi.org/10.1016/j.genrep.2020.100948
9. RASOUL, A. A., KHUDHUR, Z. O., HAMAD, M. S., ISMAEAL, Y. S., SMAIL, S. W., RASUL, M. F., MOHAMMAD, K. A., BAPIR, A. A., OMAR, S. A. & QADIR, M. K. 2021. The role of oxidative stress and haematological parameters in relapsing-remitting multiple sclerosis in Kurdish population. Multiple Sclerosis and Related Disorders, 56, 103228. https://doi.org/10.1016/j.msard.2021.103228
10. ROSHANCHESHM, S., ASADI, A., KHOSHNAZAR, S. M., ABDOLMALEKI, A., KHUDHUR, Z. O. & SMAIL, S. W. 2022. Application of natural and modified exosomes a drug delivery system. Nanomedicine Journal, 9. https://doi.org/10.22038/NMJ.2022.65116.1683
11. SAFDAR, M., KHAN, M. S., KARIM, A. Y., OMAR, S. A., SMAIL, S. W., SAEED, M., ZAHEER, S., ALI, M., AHMAD, B. & TASLEEM, M. 2021. SNPs at 3′ UTR of APOL1 and miR-6741-3p target sites associated with kidney diseases more susceptible to SARS-COV-2 infection: in silco and in vitro studies. Mammalian Genome, 32, 389-400. https://doi.org/10.1007/s00335-021-09880-6
12. SAFDAR, M., OZASLAN, M., MUSTAFA, R. M., SMAIL, S. W., KHAN, S. S., KHAN, M. S., AKHTAR, M. A., ALI, H. K., YOUNAS, U. & SAEED, M. 2023. The severity of COVID-19 in hypertensive patients is associated with mirSNPs in the 3′ UTR of ACE2 that associate with miR-3658: In silico and in vitro studies. Journal of Taibah University Medical Sciences, 18, 1030-1047. https://doi.org/10.1016/j.jtumed.2023.02.009
13. SMAIL, S., T YASEEN, R., Q MUSTAFA, M., F JALAL, K. & SALIHI, A. 2021a. Molecular Study of IL-7R Gene Polymorphism and their Associations with Male Multiple Sclerosis Patients in Erbil Province. ZANCO Journal of Pure and Applied Sciences, 33, 21-26. https://doi.org/10.21271/zjpas
14. SMAIL, S., ZIYAD ABDULQADIR, S., OMAR KHUDHUR, Z., ELIA ISHAQ, S., FAQIYAZDIN AHMED, A., GHAYOUR, M. B. & ABDOLMALEKI, A. 2023a. IL-33 promotes sciatic nerve regeneration in mice by modulating macrophage polarization. International Immunopharmacology, 123, 110711. https://doi.org/10.1016/j.intimp.2023.110711
15. SMAIL, S. W., BABAEI, E. & AMIN, K. 2023b. Ct, IL-18 polymorphism, and laboratory biomarkers for predicting chemosensory dysfunctions and mortality in COVID-19. Future Science OA, 9, FSO838. https://doi.org/10.2144/fsoa-2022-0082
16. SMAIL, S. W., BABAEI, E. & AMIN, K. 2023c. Demographic, clinical and genetic factors associated with COVID-19 disease susceptibility and mortality in a Kurdish population. Annals of Saudi Medicine, 43, 125-142. https://doi.org/10.5144/0256-4947.2023.125
17. SMAIL, S. W., BABAEI, E. & AMIN, K. 2023d. Hematological, Inflammatory, Coagulation, and Oxidative/Antioxidant Biomarkers as Predictors for Severity and Mortality in COVID-19: A Prospective Cohort-Study. International Journal of General Medicine, 565-580. https://doi.org/10.2147/IJGM.S402206
18. SMAIL, S. W., BABAEI, E., AMIN, K. & ABDULAHAD, W. H. 2023e. Serum IL-23, IL-10, and TNF-α predict in-hospital mortality in COVID-19 patients. Frontiers in Immunology, 14, 1145840. https://doi.org/10.3389/fimmu.2023.1145840
19. SMAIL, S. W., KHUDHUR, Z. O., ISHAQ, S. E., SALIH, R. H. & ABDULLAH, K. 2023f. Gender-based differences of inflammatory, coagulation, and cardiac markers in COVID-19 patients in Erbil city. Polytechnic Journal, 12, 5. https://doi.org/10.25156/ptj.v12n2y2022.pp42-46
20. SMAIL, S. W., QADIR, M. K., RAJAB, M. F., ISMAIL, I. I., TAHA, O. S., SHEKHA, M. S., KHAN, M. A. & SAFDAR, M. 2020. TGF-β1polymorphism is an inflammatory disease specifier in autism spectrum disorders? Gene Reports, 21, 100843. https://doi.org/10.1016/j.genrep.2020.100843
21. SMAIL, S. W., SAEED, M., KHUDHUR, Z. O., YOUNUS, D. A., RAJAB, M. F., ABDULAHAD, W. H., HUSSAIN, H. I., NIAZ, K. & SAFDAR, M. 2021b. Inflammation, immunity and potential target therapy of SARS-COV-2: A total scale analysis review. Food and Chemical Toxicology, 150, 112087. https://doi.org/10.1016/j.fct.2021.112087
22. Amin, O. A. H., Mirza, R. R., Hussein, H. A., Khudhur, Z. O., Awla, H. K., & Smail, S. W. (2024). Journey into the Esophageal Complications: Decoding Systemic Sclerosis with Cutting-Edge Endoscopy, Manometry, and Ambulatory pH-Study. International Journal of General Medicine, 17, 1823–1831. https://doi.org/10.2147/IJGM.S448421
23. Arash Abdolmaleki, Aida Karimian, Seyedeh Mahdieh Khoshnazar, Asadollah Asadi, Zahra Akhavi Samarein, Shukur Wasman Smail, Deepak Bhattacharya, The role of Nrf2 signaling pathways in nerve damage repair, Toxicology Research, Volume 13, Issue 3, June 2024, tfae080, https://doi.org/10.1093/toxres/tfae080
24. Smail SW, Abdulqadir SZ, Alalem LSS, Rasheed TK, Khudhur ZO, Mzury AFA, et al. Enhancing sciatic nerve regeneration with osteopontin-loaded acellular nerve allografts in rats: Effects on macrophage polarization. Tissue and Cell. 2024;88:102379.
25. Khaleel Mohammed, Z., Wasman Smail, S., Janson, C., & Amin, K. (2024). Interplay of clinical biomarkers in allergic asthma diagnosis and severity: A case-control study: Biomarkers in AA diagnosis and severity. Cellular and Molecular Biology, 70(5), 69–75. https://doi.org/10.14715/cmb/2024.70.5.10
26. Omar Khudhur Z, Ziyad Abdulqadir S, Faqiyazdin Ahmed Mzury A, Aziz Rasoul A, Wasman Smail S, Ghayour MB, et al. Epothilone B loaded in acellular nerve allograft enhanced sciatic nerve regeneration in rats. Fundamental & Clinical Pharmacology. 2024;38(2):307-19.
27. Muhammed PM, Wasman Smail S, Amin K. Deciphering COVID-19 Severity: Assessing FGF-18, WNT-5A, IL-17, and IL-33 Levels in the Infected Patients. Journal of Zankoy Sulaimani-Part A. 2023;25(2):414-22.