Researches and Books

Researches
# Research Title
1
TEC family kinases in health and disease loss-of-function of BTK and ITK and the gain-of-function fusions ITK-SYK and BTK-SYK
2
Regulation of nucleocytoplasmic shuttling of Bruton's tyrosine kinase (Btk) through a novel SH3-dependent interaction with ankyrin repeat domain 54 (ANKRD54)
3
Signaling of the ITK (interleukin 2-inducible T cell kinase)-SYK (spleen tyrosine kinase) fusion kinase is dependent on adapter SLP-76 and on the adapter function of the kinases SYK and ZAP70
4
Dual phosphorylation of Btk by Akt/protein kinase b provides docking for 14-3-3ζ, regulates shuttling, and attenuates both tonic and induced signaling in B cells
5
Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model.
6
Anti-leukaemic effects induced by APR-246 are dependent on induction of oxidative stress and the NFE2L2/HMOX1 axis that can be targeted by PI3K and mTOR inhibitors in acute myeloid leukaemia cells
7
Substitution scanning identifies a novel, catalytically active ibrutinib-resistant BTK cysteine 481 to threonine (C481T) variant.
8
Protein kinase B (AKT) regulates SYK activity and shuttling through 14-3-3 and importin 7.
9
B Cell Receptor Activation Predominantly Regulates AKT-mTORC1/2 Substrates Functionally Related to RNA Processing.
10
ANKRD54 preferentially selects Bruton's Tyrosine Kinase (BTK) from a Human Src-Homology 3 (SH3) domain library.
11
Terminating B cell receptor signaling.
12
PRIMA-1 induces apoptosis of leukemic cells via inhibiting bruton's tyrosine kinase
13
Translocation-generated ITK-FER and ITK-SYK fusions induce STAT3 phosphorylation and CD69 expression.
14
Systematic Methodological Evaluation of a Multiplex Bead-Based Flow Cytometry Assay for Detection of Extracellular Vesicle Surface Signatures
15
The global burden of childhood and adolescent cancer in 2017: an analysis of the Global Burden of Disease Study 2017
16
Mapping 123 million neonatal, infant and child deaths between 2000 and 2017
17
Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017: A Systematic Analysis for the Global Burden of Disease Study
18
The kidney injury caused by the onset of acute graft-versus-host disease is associated with down-regulation of αKlotho
19
Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017
20
Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017
21
Mapping geographical inequalities in childhood diarrhoeal morbidity and mortality in low-income and middle-income countries, 2000-17: analysis for the Global Burden of Disease Study 2017
22
Mapping geographical inequalities in oral rehydration therapy coverage in low-income and middle-income countries, 2000-17
23
Measuring universal health coverage based on an index of effective coverage of health services in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019
24
Mapping geographical inequalities in access to drinking water and sanitation facilities in low-income and middle-income countries, 2000-17
25
Five insights from the Global Burden of Disease Study 2019
26
Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950-2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019
27
Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019
28
Global burden of 87 risk factors in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019
29
The status of cancer publications in the Kurdistan region of Iraq
30
Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019: Update From the GBD 2019 Study.
31
Mapping routine measles vaccination in low- and middle-income countries
32
Cardiac, Hepatic and Renal Dysfunction and IL-18 Polymorphism in Breast, Colorectal, and Prostate Cancer Patients.
33
Short-term IL-15 priming leaves a long-lasting signalling imprint in mouse NK cells independently of a metabolic switch.
34
BTK gatekeeper residue variation combined with cysteine 481 substitution causes super-resistance to irreversible inhibitors acalabrutinib, ibrutinib and zanubrutinib.
35
Amelioration of systemic inflammation via the display of two different decoy protein receptors on extracellular vesicles.
36
Anemia prevalence in women of reproductive age in low- and middle-income countries between 2000 and 2018.
37
Global, regional, and national mortality among young people aged 10-24 years, 1950-2019: a systematic analysis for the Global Burden of Disease Study 2019.
38
Cancer Incidence in the Kurdistan Region of Iraq: Results of a Seven-Year Cancer Registration in Erbil and Duhok Governorates.
39
Global, regional, and national burden of diseases and injuries for adults 70 years and older: systematic analysis for the Global Burden of Disease 2019 Study
40
Identification of storage conditions stabilizing extracellular vesicles preparations
41
Assessment of T Cell Receptor Complex Expression Kinetics in Natural Killer Cells
42
SHP-1 localization to the activating immune synapse promotes NK cell tolerance in MHC class I deficiency
43
Prevalence, years lived with disability, and trends in anaemia burden by severity and cause, 1990-2021: findings from the Global Burden of Disease Study 2021
44
Tumor cell derived osteopontin and prostaglandin E2 synergistically promote the expansion of myeloid derived suppressor cells during the tumor immune escape phase
45
Antibody-displaying extracellular vesicles for targeted cancer therapy
46
Exploring the interplay between microRNA expression and DNA mutation analysis in AML patients
Books
# Book Title Publisher Attachements